Which of the following is NOT a clinical manifestation of Vitamin B12 deficiency anemia?

Vitamin B12 deficiency anemia presents with a variety of clinical manifestations due to its critical role in red blood cell production and neurological function. Common signs include fatigue, which occurs due to anemia caused by insufficient healthy red blood cells to transport adequate oxygen throughout the body. Peripheral neuropathy is also a significant manifestation; deficiencies in vitamin B12 can lead to neurological damage characterized by numbness or tingling in the hands and feet, as well as balance issues. Weight loss can occur as well, not solely due to a lack of appetite but also because of the overall energy depletion associated with this type of anemia.

Constipation, while possible, is not a primary or well-documented clinical manifestation of vitamin B12 deficiency anemia. It is important to recognize that gastrointestinal symptoms can arise from other deficiencies or conditions, but in the context of vitamin B12 deficiency specifically, they do not correlate as strongly as other symptoms like fatigue, neurological changes, and weight loss. Therefore, identifying constipation as not being a classic manifestation of vitamin B12 deficiency anemia aligns with the understanding of the condition's typical symptoms.