Which manifestation is specifically associated with folate deficiency?

Folate deficiency is primarily associated with angular cheilitis, which is characterized by inflammation and cracking at the corners of the mouth. This condition arises due to the role of folate in maintaining healthy skin and mucosal tissues. Folate, also known as vitamin B9, is crucial for DNA synthesis and repair, and its deficiency can lead to various hematological and dermal manifestations. Angular cheilitis can occur as a result of inadequate wound healing and skin integrity, both of which are affected by a lack of folate.

Jaundice is generally related to liver function and bilirubin metabolism, while bone deformities are typically associated with deficiencies in minerals such as calcium and vitamin D. Difficulty swallowing can stem from a variety of conditions, not specifically folate deficiency. Thus, the connection between folate deficiency and angular cheilitis highlights the specific cutaneous manifestations associated with this nutritional deficiency.