Which finding in a DRE would typically cause concern for a nurse practitioner?

The presence of a hard nodule in a Digital Rectal Exam (DRE) is significant because it may indicate potential malignancy, such as prostate cancer. Hard nodules are concerning characteristics that do not typically present in benign conditions. The size, hardness, and irregularity of a nodule increase the suspicion of an underlying pathological process.

In contrast, a soft prostate with smooth edges usually suggests normal prostate tissue or benign prostatic hyperplasia (BPH). No pain on palpation is generally a reassuring finding, as pain often suggests inflammation or other acute conditions. A rubbery quality could indicate BPH or other benign conditions; however, it is not typically as alarming as the presence of a hard nodule. Therefore, a hard nodule during a DRE represents a potential red flag that warrants further investigation, making it a critical finding for the nurse practitioner to address.