Which cells are primarily responsible for type 1 hypersensitivity reactions?

Type 1 hypersensitivity reactions, also known as immediate hypersensitivity reactions, are primarily mediated by mast cells. These cells play a crucial role in the allergic response. When an individual with a pre-existing sensitivity to an allergen is exposed to that allergen, IgE antibodies are produced and bind to mast cells. Upon subsequent exposure to the same allergen, it cross-links the IgE on the surface of mast cells, leading to their activation. This activation causes the mast cells to degranulate, releasing a variety of mediators such as histamine, leukotrienes, and prostaglandins. These mediators are responsible for the characteristic symptoms of allergic reactions, including vasodilation, increased vascular permeability, and bronchoconstriction.

In contrast, other cell types listed do not play a primary role in the immediate allergic reaction. T-cells are more involved in type 4 hypersensitivity (cell-mediated immunity) rather than type 1. Eosinophils typically participate in responses to parasitic infections and play a role in inflammation in allergic asthma but are not the main drivers of the immediate hypersensitivity response. Neutrophils are key players in the innate immune response, particularly in fighting infections and mediating inflammation, but they