What condition can lead to the progression of chronic kidney disease due to an inability to excrete uric acid?

The correct answer is associated with the inability to effectively excrete uric acid, which plays a significant role in the development and progression of chronic kidney disease (CKD). Gout is a form of inflammatory arthritis characterized by the accumulation of uric acid crystals in the joints, resulting from elevated levels of uric acid in the bloodstream—known as hyperuricemia.

In individuals with chronic kidney disease, the kidneys' ability to filter and excrete uric acid is compromised. When the kidneys are not functioning properly, uric acid can build up, leading to hyperuricemia. This excess uric acid can not only contribute to the painful episodes of gout but can also exacerbate kidney function impairment. The presence of uric acid crystals can lead to further inflammation and injury in the kidneys, further complicating the progression of kidney disease.

Effective management of uric acid levels is crucial in patients with chronic kidney disease to prevent additional strain on renal function and mitigate the risk of gout flare-ups. Therefore, hyperuricemia and its related complications, primarily manifested in gout, are directly linked to the worsening of chronic kidney disease.